{"id":639,"date":"2017-12-19T10:38:50","date_gmt":"2017-12-19T08:38:50","guid":{"rendered":"http:\/\/blogs.uct.ac.za\/cancerphd\/?p=639"},"modified":"2017-12-19T10:55:09","modified_gmt":"2017-12-19T08:55:09","slug":"639","status":"publish","type":"post","link":"https:\/\/blogs.uct.ac.za\/cancerphd\/2017\/12\/639\/","title":{"rendered":"Fusobacterium nucleatum and Colorectal Cancer"},"content":{"rendered":"<h1><span style=\"color: #008000;\"><strong>Oral Bacteria Found Predominantly Associated with Human Colorectal Cancer Cells<\/strong><\/span><\/h1>\n<p><em>By Ramadhani Chambuso<\/em><\/p>\n<p>The same oral commensal bacterium and gum disease pathogen called <em>Fusobacterium nucleatum<\/em> was found to be predominantly associated with primary human colorectal cancer cells and even in distant metastatic lesions, a study published in 2017 on\u00a0the journal <em>Science<\/em>, reports. Furthermore, it was proven in mice with colon cancer that after treatment with antibiotics, <em>Fusobacteruim<\/em> load, cancer cell proliferation and overall tumour growth, all were reduced, which indicates that this organism may play a crucial role in colon cancer development.<\/p>\n<p>Despite other studies suggesting the possible pro-tumorigenic role of <em>Fusobacterium<\/em> which may include modulation of host immune response to cancer cells and further enhancement of tumour cell invasion in colon cancer pathogenesis, this new study was scientifically able to show the correlation between decrease in <em>Fusobacterium<\/em> load and the decreased in rate of tumour growth and improved overall patient survival.<\/p>\n<p>Although it is not clear yet if good oral hygiene would probably add advantage to preventive measures to colorectal cancer outcome, these scientists recommended the use of antibiotic Metronidazole, <em>Fusobacterium<\/em>\u2013specific antimicrobial agents or phage therapy concurrently in colon cancer treatment. This is because broad-spectrum antibiotics may risk other gut microbial balance and did not show any additional effects on tumour growth control in their study.<\/p>\n<p>Source:\u00a0<a href=\"http:\/\/science.sciencemag.org\/content\/early\/2017\/11\/20\/science.aal5240\">Bullman et al. (2017)<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26311717\">Mima et al. (2015)<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Oral Bacteria Found Predominantly Associated with Human Colorectal Cancer Cells By Ramadhani Chambuso The same oral commensal bacterium and gum disease pathogen called Fusobacterium nucleatum was found to be predominantly &hellip; <a href=\"https:\/\/blogs.uct.ac.za\/cancerphd\/2017\/12\/639\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Fusobacterium nucleatum and Colorectal Cancer<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"ngg_post_thumbnail":0,"footnotes":""},"categories":[1],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Fusobacterium nucleatum and Colorectal Cancer - Postgraduate Cancer Research Initiative (CRI) blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.uct.ac.za\/cancerphd\/2017\/12\/639\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Fusobacterium nucleatum and Colorectal Cancer - Postgraduate Cancer Research Initiative (CRI) blog\" \/>\n<meta property=\"og:description\" content=\"Oral Bacteria Found Predominantly Associated with Human Colorectal Cancer Cells By Ramadhani Chambuso The same oral commensal bacterium and gum disease pathogen called Fusobacterium nucleatum was found to be predominantly &hellip; 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